PathwayStep6408 PathwayStep6405 Microtubule-independent trafficking of connexons to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Transport of connexons to the plasma membrane Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09 Edited: Matthews, L, 2007-04-12 12:57:50 Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995). Pubmed12149451 Pubmed17289573 Pubmed7691412 Pubmed8404537 Pubmed8522583 Reactome Database ID Release 43190872 Reactome, http://www.reactome.org ReactomeREACT_11050