PathwayStep6398 PathwayStep6399 Transport of connexins to the Trans-Golgi Network (TGN) Transport of connexins to the ER-Golgi intermediate compartment Transport of connexins along the secretory pathway Authored: Gilleron, J, Segretain, D, Falk, MM, 2007-01-03 12:23:09 Connexins follow the classical secretory transport route from the ER to the plasma membrane: ER -> ERGIC -> Golgi -> TGN (Trans Golgi Network) -> PM (Plasma Membrane). All connexins assemble or oligomerize into hexameric connexons. The site of assembly varies and depends on Cx isoform, or cell type (see Koval et al., 2006).<br>Oligomerization of connexins has been observed during ER membrane insertion (Cx32), just after exit from the ER, in the ER-Golgi-intermediate compartment (Cx26) and inside the Trans-Golgi Network (Cx43) (Falk et al. 1997; Ahmad et al. 1999; Musil and Goodenough 1993; Diez et al. 1999). Edited: Matthews, L, 2007-01-26 11:57:49 Pubmed10191254 Pubmed10231375 Pubmed16490353 Pubmed7691412 Pubmed9184217 Reactome Database ID Release 43190827 Reactome, http://www.reactome.org ReactomeREACT_9392