PathwayStep6305 PathwayStep6307 PathwayStep6306 PathwayStep6309 PathwayStep6308 PathwayStep6310 HNF1B- and FGF10-dependent synthesis of PTF1A protein HNF1B-dependent synthesis of HNF6 protein HNF6- and FGF10-dependent synthesis of PDX1 protein HNF6-dependent synthesis of ONECUT3 protein during early pancreas specification PDX1-dependent synthesis of NKX6-1 protein PDX1-dependent synthesis of NR5A2 protein Regulation of gene expression in early pancreatic precursor cells Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 GENE ONTOLOGYGO:0031018 Pubmed12591178 Pubmed15298336 Reactome Database ID Release 43210747 Reactome, http://www.reactome.org ReactomeREACT_13778 Reviewed: Jensen, J, 2008-05-12 21:46:53 The properties of transcriptional networks early in the differentiation of human pancreatic cells are inferred from the properties of well-studied networks in mouse models. In mice, the first visible sign of pancreatic development is the appearance of pancreatic buds at about embryonic day 9. The cells in these buds are already committed to differentiate into specialized cells of the exocrine and endocrine pancreas. Expression of transcription factors including Hnf1b, Hnf6, and Pdx1, as well as responsiveness to Fgf10 (fibroblast growth factor 10), up-regulates the expression of factors including Ptf1, Onecut3, Lrh1, and Nkx6.1 (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003).