IN viral DNA:Ku proteins:XRCC4:DNA ligase IV complex 2-LTR form of circular viral DNA XRCC4:DNA ligase IV complex Ku70:Ku80 heterodimer 2-LTR formation due to circularization of viral DNA Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Pubmed16291214 Reactome Database ID Release 43175258 Reactome, http://www.reactome.org ReactomeREACT_9073 Reviewed: Bushman, FD, 2006-10-30 22:19:13 Viral DNA that does not become integrated can undergo another fate, which is to have the two viral DNA ends joined together to form a 2-LTR circle. This reaction requires Ku, XRCC4 and ligase 4. has a Stoichiometric coefficient of 2