PathwayStep6334 PathwayStep6333 PathwayStep6332 PathwayStep6331 PathwayStep6330 PathwayStep6328 PathwayStep6329 PathwayStep6326 PathwayStep6327 PathwayStep6324 PathwayStep6325 PDX1-dependent synthesis of NKX6-1 protein NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein PDX1-dependent synthesis of IAPP protein FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein HNF1A-dependent synthesis of HNF4G protein HNF1A-dependent synthesis of FOXA3 HNF1A-dependent synthesis of GLUT2 protein HNF1A-dependent synthesis of the L isoform of PKLR protein HNF1A-dependent synthesis of HNF4A Regulation of gene expression in beta cells Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 GENE ONTOLOGYGO:0031018 Pubmed12591178 Pubmed15298336 Reactome Database ID Release 43210745 Reactome, http://www.reactome.org ReactomeREACT_13819 Reviewed: Jensen, J, 2008-05-12 21:46:53 Two transcription factors, PDX1 and HNF1A, play key roles in maintaining the gene expression pattern characteristic of mature beta cells in the endocrine pancreas. Targets of these regulatory molecules include genes encoding insulin, the GLUT2 glucose transporter, the liver- (and pancreas) specific form of pyruvate kinase and other transcription factors including HNF4A, HNF4G, and FOXA3. PDX1 expression in turn is controlled by the activities of MAFA, FOXA2, and PAX6, and negatively regulated via AKT (Chakrabarti and Mirmira 2003; Servitja and Ferrer 2004). AKT-mediated inactivation of FOXO1A