PathwayStep6322 PathwayStep6323 AKT phosphorylates FOXO1A Phosphorylated FOXO1A is excluded from the nucleus AKT-mediated inactivation of FOXO1A Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 Pubmed12228231 Reactome Database ID Release 43211163 Reactome, http://www.reactome.org ReactomeREACT_13655 Reviewed: Jensen, J, 2008-05-12 21:46:53 The unphosphorylated form of FOXO1A shuttles between the nucleus and cytoplasm, maintaining a substantial concentration of this protein in the nucleoplasm, where it functions as a transcription factor. Phosphorylation of the protein, catalyzed by activated AKT, causes its exclusion from the nucleus (Zhang et al. 2002).