PathwayStep6312 PathwayStep6313 PathwayStep6314 PathwayStep6315 HNF6-dependent synthesis of ONECUT3 protein during morphogenesis HNF6-dependent synthesis of HNF1B protein HNF6-dependent synthesis of NEUROG3 protein during morphogenesis RBPJ- and NOTCH1-dependent synthesis of HES1 protein during morphogenesis Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5- Edited: D'Eustachio, P, 2008-05-12 21:43:33 GENE ONTOLOGYGO:0031018 Pubmed12591178 Pubmed15298336 Reactome Database ID Release 43210744 Reactome, http://www.reactome.org ReactomeREACT_13673 Reviewed: Jensen, J, 2008-05-12 21:46:53 The properties of transcriptional networks in late stage (branching morphogenesis) pancreatic bud precursor cells are inferred from the properties of well-studied networks in mouse models. In mice, committed but undifferentiated epithelial cells are organized into branching ductal structures. At a molecular level, expression of Pdx1, Nkx2.2, and Nkx6.1 is reduced while Hnf6 expression remains high. Hnf6 mediates the continued expression of Onecut3 and Hnf1 beta and epithelial cell proliferation. As expression of Ngn3 (corresponds to human NEUROG3) rises, endocrine differentiation of the epithelial cells begins (Servitja and Ferrer 2004; Chakrabarti and Mirmira 2003).