PathwayStep6345 PathwayStep6344 PathwayStep6343 LEFTY Binds the EGF-CFC Coreceptor in the NODAL Receptor CERBERUS Binds NODAL LEFTY Binds NODAL Regulation of Signaling by NODAL Authored: May, B, 2011-07-11 Edited: May, B, 2011-07-11 Mature NODAL can form heterodimers with LEFTY1, LEFTY2, or CERBERUS. The heterodimers do not activate the NODAL receptor. LEFTY1 and LEFTY2 also bind CRIPTO and CRYPTIC coreceptors and prevent them from interacting with other components of the NODAL receptor. By these mechanisms LEFTY1, LEFTY2, and CERBERUS negatively regulate NODAL signaling (reviewed in Shen 2007, Schier 2009). Pubmed17287255 Pubmed20066122 Reactome Database ID Release 431433617 Reactome, http://www.reactome.org ReactomeREACT_111059 Reviewed: May, B, 2011-08-18