PathwayStep6390 PathwayStep6391 PathwayStep6376 PathwayStep6388 PathwayStep6389 PathwayStep6383 Vamp8 associated secretory vesicle to plasma membrane transport Vamp7 associated Lysosome to Plasma membrane transport Vamp2 associated secretory vesicle to plasma membrane transport trans-Golgi Network Coat Activation Clathrin derived vesicle budding Authored: Gillespie, ME, 2009-08-27 Edited: Gillespie, ME, 2009-08-14 Reactome Database ID Release 43421837 Reactome, http://www.reactome.org ReactomeREACT_19187 Reviewed: Rush, MG, 2008-01-11 00:00:00 Reviewed: Simpson, JC, 2009-08-27 There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. Golgi Associated Vesicle Biogenesis Lysosome Vesicle Biogenesis