RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA RTC with duplex DNA containing discontinuous plus strand flap Synthesis of full-length duplex viral DNA with a discontinuous plus strand After the second jump, elongation of the plus and minus strands continues. The elongation process requires strand displacement, which RT can mediate, at least in vitro (Huber et al. 1989; Hottiger et al. 1994; Rausch and Le Grice 2004). The final product is a blunt-ended linear duplex DNA with a discontinuity in its "plus" strand at the site of the cPPT sequence motif. Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 EC Number: 2.7.7.7 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Pubmed10723025 Pubmed15183342 Pubmed2466838 Pubmed7507115 Reactome Database ID Release 43164505 Reactome, http://www.reactome.org ReactomeREACT_8992 Reviewed: Hughes, SH, 2006-10-30 22:00:51