IN bound to sticky 3' ends of viral DNA in PIC Import of PIC to the Host Nucleus Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 GENE ONTOLOGYGO:0051169 HIV can infect non-dividing cells, implying that the PIC must be able to traverse the nuclear membrane. In contrast, simple retroviruses such as MLV can only infect cells once they have passed through mitosis, potentially because they require breakdown of the nucleus to access chromosomal integration sites. The mechanism of nuclear localization is controversial. A variety of proposals have been made for nuclear localization sequences (NLS) in the PIC, but most of those have now been shown to be dispensible for HIV integration. According to a new idea from Yamashita and Emerman, it may be that the PIC is imported into the nucleus by a default pathway, while MLV PICs are retained in the cytoplasm because capsid protein is stably associated with PICs.<br> Pubmed15140964 Pubmed16291214 Pubmed16292356 Pubmed16364740 Pubmed8491198 Reactome Database ID Release 43162590 Reactome, http://www.reactome.org ReactomeREACT_9004 Reviewed: Bushman, FD, 2006-10-30 22:19:13 IN bound to sticky 3' ends of viral DNA in PIC