IN bound to sticky 3' ends of viral DNA in PIC viral DNA bound with Integrase in PIC Terminal (3' end) cleavage of viral DNA Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Prior to integration, two nucleotides are removed from each 3' end of the linear viral DNA, thereby exposing recessed 3' hydroxyls. This reaction may serve to remove heterogenous extra bases from the viral DNA end, and to stabilize the IN-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification. Pubmed16482214 Pubmed1760846 Pubmed2539592 Pubmed8041787 Pubmed8883604 Pubmed9188609 Reactome Database ID Release 43164522 Reactome, http://www.reactome.org ReactomeREACT_9069 Reviewed: Bushman, FD, 2006-10-30 22:19:13