PIC (PreIntegration Complex) viral DNA bound with Integrase in PIC Integrase binds viral DNA ends Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Pubmed1533044 Pubmed16482214 Pubmed2171144 Pubmed8883604 Reactome Database ID Release 43164514 Reactome, http://www.reactome.org ReactomeREACT_9074 Reviewed: Bushman, FD, 2006-10-30 22:19:13 Upon completion of reverse transcription, the viral integrase protein (IN) becomes bound to the ends of the viral DNA. This is inferred by the fact that this is the site of integrase action, and several biochemical studies have documented integrase interactions with the terminal DNA.