Ku proteins bound to viral DNA Ku70:Ku80 heterodimer viral PIC proteins Association of Ku heterodimer with viral DNA ends Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Pubmed11406603 Reactome Database ID Release 43175174 Reactome, http://www.reactome.org ReactomeREACT_9022 Reviewed: Bushman, FD, 2006-10-30 22:19:13 The Ku protein can be found bound to active PICs in the cytoplasm. However, ligation of the viral DNA ends to form 2-LTR circles takes place in the nucleus. IN bound to sticky 3' ends of viral DNA in PIC