RTC with degraded RNA template and minus sssDNA RTC with minus sssDNA transferred to 3'-end of viral RNA template First strand transfer mediated by Repeated (R) sequence Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 Pubmed10954531 Pubmed10982320 Pubmed7510065 Pubmed7535765 Reactome Database ID Release 43164503 Reactome, http://www.reactome.org ReactomeREACT_9033 Reviewed: Hughes, SH, 2006-10-30 22:00:51 The minus strand strong stop DNA (-sssDNA) is transferred to the 3' end of the HIV-1 genomic RNA, where the 3' end of the -sssDNA anneals to the viral genomic R sequence motif (Ghosh et al. 1995; Klaver and Berkhout 1994; Ohi and Clever 2000; Telesnitsky and Goff 1997). Viral NC (nucleocapsid) protein may play a role in this transfer (Driscoll and Hughes 2000).