Phospho-MEF2 MEF2 ERK5 activates the transcription factor MEF2 Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 2.7.11 Reactome Database ID Release 43199929 Reactome, http://www.reactome.org ReactomeREACT_12413 Reviewed: Greene, LA, 2007-11-08 15:39:37 The MEF2 (Myocyte-specific enhancer factor 2) proteins constitute a family of transcription factors: MEF2A, MEF2B, MEF2C, and MEF2D. MEF2A and MEF2C are known substrates of ERK5, and their transactivating activity can be stimulated by ERK5 via direct phosphorylation. MEF2A and MEF2C are expressed in developing and adult brain including cortex and cerebellum.