Phospho-ELK1 ELK1 ERK1/2 activates ELK1 Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 EC Number: 2.7.11 Following translocation to the nucleus, ERK1/2 directly phosphorylates key effectors, including the ubiquitous transcription factors ELK1 (Ets like protein 1). At least five residues in the C terminal domain of ELK1 are phosphorylated upon growth factor stimulation. ELK1 can form a ternary complex with the serum response factor (SRF) and consensus sequences, such as serum response elements (SRE), on DNA, thus stimulating transcription of a set of immediate early genes like c fos. Reactome Database ID Release 43198731 Reactome, http://www.reactome.org ReactomeREACT_12406 Reviewed: Greene, LA, 2007-11-08 15:39:37 has a Stoichiometric coefficient of 5