GFRalpha NCAM1:GFRalpha-1 Interaction of NCAM1 with GFRalpha-1 Authored: Garapati, P V, 2009-02-24 10:31:15 Edited: Garapati, P V, 2009-02-24 10:58:20 GFRalpha receptors GFRalpha1 and possibly also GFRalpha2 and GFRalpha4 subunit of the GDNF (glial cell line-derived neurotrophic factor) receptor interact in cis with NCAM and functions as a coreceptor for GDNF in the absence of RET. The NCAM1-GFRalpha1 interaction down regulates NCAM1-mediated cell adhesion and promotes GDNF-NCAM1 binding. Pubmed12837245 Reactome Database ID Release 43375149 Reactome, http://www.reactome.org ReactomeREACT_18304 Reviewed: Maness, PF, Walmod, PS, 2009--0-5-