DCC:Netrin-1 DCC interaction with Netrin-1 Authored: Garapati, P V, 2008-09-05 06:02:05 Edited: Garapati, P V, 2008-07-30 10:24:23 Edited: Garapati, P V, 2008-09-05 06:02:05 Netrin-1 promotes attraction of the commissural neurons to midline cells. It is secreted in the ventral midline (also known as the floor plate). The transmembrane DCC receptor is a Netrin-1 receptor, involved in the attractive effects of Netrin-1. Contact-dependent mechanisms promote extension of growth cones across the floor plate to the contralateral side, whereupon growth cones acquire sensitivity to the midline repellent Slit and grow away from the midline.<br>Netrin-1 binds directly to the fifth Fibronectin III motif of DCC, thereby inducing DCC clustering through the association between the DCC P3 domains, a process required for an attractive response. Pubmed11239160 Pubmed9950216 Reactome Database ID Release 43373711 Reactome, http://www.reactome.org ReactomeREACT_22153 Reviewed: Cooper, HM, 2010-02-16