L1:clathrin-coated vesicle Clathrin-coated vesicle L1 binds to AP-2 Clathrin complex Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 L1 in the C-domain membrane is internalized via clathrin mediated endocytosis. The assembly of clathrin coats at the plasma membrane depends on the adaptor complex AP-2 which is composed of two large chains (alpha and beta1 or beta2 adaptin), one medium (mu2) chain, and one small chain (sigma2). When dephosphorylated, the sorting signal/endocytic motif YRSLE sequence enables L1 to directly bind the mu2 subunit of AP-2, and concentrates L1 molecules in clathrin coated areas of the plasma membrane. Pubmed9651214 Reactome Database ID Release 43392748 Reactome, http://www.reactome.org ReactomeREACT_22118 Reviewed: Maness, PF, 2010-02-16