PathwayStep5078 PathwayStep5079 Dissociation of phosphorylated 4EBP1 from eIF4E Phosphorylation of 4E-BP1 by activated mTORC1 Release of eIF4E Raptor recruits mTOR to non-phosphorylated 4E-BP1 bound to eIF4E and positively modulates phosphorylation of 4E-BP1 by mTOR. 4E-BP1 is further phosphorylated on multiple sites by other unknown kinases, also contributing to the dissociation of 4E-BP1 from eIF4E. Thus mTORC1 relieves the inhibitory effect of 4E-BP1 on eIF4E dependent translation initiation (PMIDs 15755954, 10872469, 11297505, 12150926 and 15809305). Reactome Database ID Release 43165721 Reactome, http://www.reactome.org ReactomeREACT_6836