L1:NUMB:CRMP-2:alpha-adaptin CRMP-2:NUMB:alpha adaptin Interaction of NUMB with L1 Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 Numb is thought to be a phosphotyrosine binding (PTB) domain containing cargo specific adaptor protein, which links specific cargo to the endocytic machinery. It associates with collapsin response mediator protein-2 (CRMP 2) with its PTB domain and alpha adaptin (a subunit of the AP 2 adaptor complex) through its tripeptide Asp-Pro-Phe (DPF) motif, and is involved in clathrin dependent endocytosis at the plasma membrane. Numb is associated with L1 under physiological conditions and functions in endocytosis of L1 in the C domain membrane of axonal growth cones. Pubmed12942088 Reactome Database ID Release 43443783 Reactome, http://www.reactome.org ReactomeREACT_22358 Reviewed: Maness, PF, 2010-02-16