Insulin degradation PathwayStep5113 PathwayStep5112 PathwayStep5115 PathwayStep5114 PathwayStep5116 Endosome acidification Re-integration of insulin receptor into plasma membrane Dissociation of insulin from insulin receptor Insulin receptor de-phosphorylation Insulin receptor recycling Authored: Bevan, AP, 2003-07-31 08:01:55 Reactome Database ID Release 4377387 Reactome, http://www.reactome.org ReactomeREACT_1109 Triggered by acidification of the endosome, insulin dissociates from the receptor and is degraded. The receptor is dephosphorylated and re-integrated into the plasma membrane, ready to be activated again by the binding of insulin molecules.