PathwayStep5105 PathwayStep5106 PathwayStep5107 PathwayStep5108 PathwayStep5104 PathwayStep5103 SOS phosphorylation and dissociation (SHC) SOS phosphorylation and dissociation (IRS) De-phosphorylation of SHC SOS phosphorylation and dissociation (IRS, Crk) Binding of Grb10 to the insulin receptor De-phosphorylation of IRS Signal attenuation Authored: 2003-07-28 10:05:14 Now with the complete receptor-ligand dissociation and subsequent degradation of insulin in the endosomal lumen, the endosomally associated protein tyrosine phosphatases (PTPs) complete the receptor dephosphorylation. So too are all the receptor substrates dephosphorylated leading to the collapse of the signalling complexes and signal attenuation. Reactome Database ID Release 4374749 Reactome, http://www.reactome.org ReactomeREACT_508