Phosphorylation of L1 by SRC Authored: Garapati, P V, 2008-07-30 10:22:58 EC Number: 2.7.10 Edited: Garapati, P V, 2008-07-30 10:22:58 Pubmed12082080 Reactome Database ID Release 43445084 Reactome, http://www.reactome.org ReactomeREACT_22408 Reviewed: Maness, PF, 2010-02-16 The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.