PathwayStep5089 PathwayStep5086 Regulation of Rheb GTPase activity by AMPK Regulation of AMPK activity via LKB1 Energy dependent regulation of mTOR by LKB1-AMPK Authored: Katajisto, P, Makela, T, Wu, J, 2008--1-1- Edited: Jassal, B, 2008-11-19 15:14:38 GENE ONTOLOGYGO:0007050 Pubmed17010524 Pubmed17613433 Pubmed17712357 Reactome Database ID Release 43380972 Reactome, http://www.reactome.org ReactomeREACT_21387 Reviewed: Zheng, B, 2009-10-20 Upon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. If the AMP:ATP ratio rises, this activation is maintained and AMPK activates the TSC complex by phosphorylating TSC2. Active TSC activates the intrinsic GTPase activity of Rheb, resulting in GDP-loaded Rheb and inhibition of mTOR pathway.