PathwayStep5101 PathwayStep5062 IRS-related events Authored: Bevan, AP, 2003-07-31 08:01:55 IRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned under IRS are examples of IRS family members acting as indicated. More family members are to be confirmed and added in the future. Reactome Database ID Release 4377389 Reactome, http://www.reactome.org ReactomeREACT_762 IRS-mediated signalling IRS activation