PathwayStep5065 PathwayStep5091 mTOR signalling PDE3B signalling PKB-mediated events Authored: Scott, J, Tatoud, R, 2005-05-09 06:03:17 PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools. Reactome Database ID Release 43109703 Reactome, http://www.reactome.org ReactomeREACT_456