PathwayStep5164 PathwayStep5163 PathwayStep5166 PathwayStep5165 NF-kB migrates to the nucleus and turns on transcription IkB is ubiquitinated and degraded IKKbeta phosphorylates IkB causing NF-kB to dissociate IKKbeta is activated NF-kB is activated and signals survival Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 Pubmed16187223 Reactome Database ID Release 43209560 Reactome, http://www.reactome.org ReactomeREACT_13696 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46 Upon activation in response to NGF, NF-kB moves to the nucleus, where it turns on genes that promote survival, and triggers the expression of HES1/5 to modulate dendritic growth.