PathwayStep5170 PathwayStep5169 Sphingomyelinase is activated by the NGF:p75NTR complex Production of ceramide which can activate JNK and other targets Ceramide signalling Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 GENE ONTOLOGYGO:0008624 In certain cell types, ligand binding to p75NTR leads to ceramide production, which can mediate either cell survival (e.g. in noecotical subplate neurons) or apoptosis (e.g. in oligodendrocytes). Low levels of ceramide are also able to stimulate axonal outgrowth in hippocampal neurons. Pubmed12676795 Reactome Database ID Release 43193681 Reactome, http://www.reactome.org ReactomeREACT_13806 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46