PathwayStep5197 PathwayStep5241 PathwayStep5246 PathwayStep5245 PathwayStep5238 PathwayStep5227 PathwayStep5236 PathwayStep5230 Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 Pubmed10579918 Pubmed10851172 Pubmed11520933 Pubmed12676795 Reactome Database ID Release 43187037 Reactome, http://www.reactome.org ReactomeREACT_12056 Reviewed: Greene, LA, 2007-11-08 15:39:37 Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the likely outcome of short term signalling, as observed following stimulation of EGFR (EGF receptor). Long term signalling via TRK receptors, instead, was clearly shown to be required for neuronal differentiation in response to neurotrophins. Nuclear Events (kinase and transcription factor activation) Retrograde neurotrophin signalling Signalling to ERK5 Signalling to STAT3 Signalling to ERKs PI3K/AKT activation PLC-gamma1 signalling