PathwayStep5179 PathwayStep5178 PathwayStep5177 PathwayStep5176 PathwayStep5175 Myelin components can interact with p75NTR:NgR:LINGO1 The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA p75NTR interacts with the NOGO receptor p75NTR:NgR complex interacts with the axonal inhibitor LINGO1 RhoA is activated by nucleotide exchange and inhibits axonal growth Axonal growth inhibition (RHOA activation) Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 GENE ONTOLOGYGO:0050771 Pubmed12951563 Reactome Database ID Release 43193634 Reactome, http://www.reactome.org ReactomeREACT_13815 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46 p75NTR can also form a receptor complex with the Nogo receptor (NgR). Such complexes mediates axonal outgrowth inhibitory signals of MDGIs (myelin-derived growth-inhibitors), such as Nogo66, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMGP).