L1:NP-1 L1 binds Neuropilin-1 Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 L1 interacts with neuropilin 1 (NP-1) through a conserved sequence (FASNKL) present with in the Ig1 domain of L1 and this association is required as a part of semaphorin 3A (Sema3A) receptor complex for axon guidance responses. <br>L1 interacts with NP-1 in cis to form a receptor complex that induces repulsive turning of the growth cone in response to Sema3A binding, whereas trans interaction of L1 with NP-1 switches Sema3A triggered repulsion to attraction. Pubmed12456642 Reactome Database ID Release 43374669 Reactome, http://www.reactome.org ReactomeREACT_22257 Reviewed: Maness, PF, 2010-02-16