L1-EGFR trans-heterodimer L1-EGFR trans-heterodimerization Authored: Garapati, P V, 2008-07-30 10:22:58 Edited: Garapati, P V, 2008-07-30 10:22:58 L1CAM and EGFR engage in a weak heterophilic trans interaction and this induces EGFR tyrosine kinase activity and its activation. However, this trans interaction alone is not sufficient to induce EGFR autophosphorylation, which requires additional cis type interactions between the two proteins. Pubmed14718570 Reactome Database ID Release 43445069 Reactome, http://www.reactome.org ReactomeREACT_22196 Reviewed: Maness, PF, 2010-02-16