PathwayStep5191 PathwayStep5190 PathwayStep5192 PathwayStep5189 beta-NGF dimer binds to TrkA receptor The bound receptor dimerizes TrkA receptor autophosphorylates Activated TrkA receptor internalizes to endosomes TRKA activation by NGF Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 GENE ONTOLOGYGO:0048011 Neurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. NGF binds to TRKA, BDNF and NT4 bind to TRKB, NT3 binds to TRKC. A tri-molecular signalling complex (NGF-p75NTR-TRKA) might also be possible. Pubmed1315923 Pubmed1844238 Reactome Database ID Release 43187042 Reactome, http://www.reactome.org ReactomeREACT_11060 Reviewed: Greene, LA, 2007-11-08 15:39:37