CHL1:alpha1beta1/alpha2beta1 integrins Integrins alpha1beta1, alpha2beta1 CHL1 interacts with beta1 integrins Authored: Garapati, P V, 2008-07-30 10:22:58 CHL1 interacts with alpha1beta1/alpha2beta1 integrins in cis on the cell surface and promotes intracellular signaling, which stimulates cell migration on extracellular matrix proteins such as collagen-I. The integrin interaction motif, DGEA in the Ig6 domain of CHL1, is necessary to potentiate migration to collagen-I. CHL1 interacts with integrins to mediate radial migration of neural precursors in the development neocortex, and suppresses neuronal branching during migration. Edited: Garapati, P V, 2008-07-30 10:22:58 Pubmed12721290 Pubmed15504324 Reactome Database ID Release 43445088 Reactome, http://www.reactome.org ReactomeREACT_22369 Reviewed: Maness, PF, 2010-02-16