PathwayStep5119 PathwayStep5123 PathwayStep5120 PathwayStep5121 PathwayStep5122 Pro-beta-NGF and mature beta-NGF are secreted pro-beta-NGF dimerizes The signal peptide is excised from beta-NGF pre-pro-precursor Part of pro-beta-NGF is processed to mature beta-NGF pro-beta-NGF homodimer transits to the golgi apparatus NGF processing All neurotrophins (NTs) are generated as pre-pro-neurotrophin precursors. The signal peptide is cleaved off as NT is associated with the endoplasmic reticulum (ER). The resulting pro-NT can form a homodimer spontaneously which then transits to the Golgi apparatus and then onto the trans-Golgi network (TGN). Resident protein convertases (PCs) can cleave off the pro-sequence and mature NT is is targeted to constitutively released vesicles. The pro-NT form can also be released to the extracellular region. Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 GENE ONTOLOGYGO:0032455 Pubmed12787574 Reactome Database ID Release 43167060 Reactome, http://www.reactome.org ReactomeREACT_11062 Reviewed: Greene, LA, 2007-11-08 15:39:37