PathwayStep5129 PathwayStep5128 PathwayStep5134 PathwayStep5132 PathwayStep5133 PathwayStep5130 PathwayStep5131 Active JNK moves to the nucleus and phosphorylates different transcription factors JNK phosphorylates BIM, BAD and other targets GTP-bound RAC contributes to JNK activation p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor NRAGE activates JNK NRAGE sequesters CHE1 in the cytoplasm NGF:p75NTR complex binds to NRAGE NRAGE signals death through JNK Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 GENE ONTOLOGYGO:0006915 Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here. Pubmed12376548 Reactome Database ID Release 43193648 Reactome, http://www.reactome.org ReactomeREACT_13638 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46