PathwayStep5144 PathwayStep5145 PathwayStep5146 p75NTR binds to NADE 14-3-3epsilon attentuates NADE-related apoptosis p75NTR:NADE promotes caspase2/3 activation NADE modulates death signalling Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 GENE ONTOLOGYGO:0006915 NADE protein (p75NTR-associated cell death executor) may induce cell death upon NGF binding, but not BDNF, NT3, or NT4/5 binding, to p75NTR. The NADE-dependent apoptosis is modulated by the 14-3-3-epsilon protein (Kimura MT et al, 2001). Pubmed11278287 Reactome Database ID Release 43205025 Reactome, http://www.reactome.org ReactomeREACT_13526 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46