PathwayStep5136 PathwayStep5137 PathwayStep5139 PathwayStep5138 PathwayStep5140 PathwayStep5141 PathwayStep5142 Polyubiquitinated NRIF migrates to the nucleus Polyubiquitinated NRIF binds to p62 (Sequestosome) TRAF6 polyubiquitinates NRIF gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 NRIF and TRAF6 may activate JNK TRAF6 binds to p75NTR:NRIF NRIF binds to p75NTR NRIF signals cell death from the nucleus Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 GENE ONTOLOGYGO:0006915 NRIF (nuclear receptor-interacting factor) is a DNA binding protein that is essential for p75-mediated apoptosis in retina and sympathetic neurons. Neurotrophin or proneurotrophin binding to p75TR induces nuclear translocation of NRIF, which involves gamma-secretase cleavage of p75NTR ICD (Intra Cellular Domain). Once in the nucleus, NRIF mediates apoptosis, probably by acting as transcription factor. Pubmed15721744 Reactome Database ID Release 43205043 Reactome, http://www.reactome.org ReactomeREACT_13643 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46