PathwayStep5154 PathwayStep5155 PathwayStep5153 PathwayStep5158 PathwayStep5159 PathwayStep5156 PathwayStep5157 PathwayStep5160 PathwayStep5161 p62 is recruited and forms a complex with TRAF6 MYD88 dissociates IRAK interacts with TRAF6 IKK-beta is recruited p62 recruits an atypical PKC TRAF6 is auto-ubiquitinated p75NTR interacts with RIP2 IRAK is activated p75NTR interacts with IRAK:MYD88 p75NTR recruits signalling complexes Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2008-05-20 12:26:36 NF-kB activation involves recruitment at the cell membrane of several proteins such as RIP2, MYD88, IRAK1, TRAF6, p62 and atypical PKC by the NGF:p75NTR complex. Reactome Database ID Release 43209543 Reactome, http://www.reactome.org ReactomeREACT_13415 Reviewed: Chao, MV, 2008-05-28 09:46:01 Reviewed: Friedman, WJ, 2008-05-20 12:23:46