DAG and IP3 signaling RAF/MAP kinase cascade PIP3 activates AKT signaling PathwayStep5258 PathwayStep5269 PathwayStep5268 PathwayStep5267 PathwayStep5266 PathwayStep5265 PathwayStep5264 PathwayStep5263 PathwayStep5262 PathwayStep5261 PathwayStep5260 PathwayStep5259 PathwayStep5273 PathwayStep5270 PathwayStep5272 PathwayStep5271 Crk binds to the active PDGF receptor p130Cas and C3G bind PDGFR bound Crk Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) STAT binds to the active receptor Nck binds to the active PDGF receptor Grb7 binds to the active PDGF receptor GAP binds to PDGF-beta receptors only Grb2/Sos1 complex binds to the active receptor Activation of Src SHP2 binds to the active receptor PI3-kinase binds to the active receptor PI3K catalyses the phosphorylation of PIP2 to PIP3 PLC-gamma binds to the active receptor Phosphorylation of PLCgamma by PDGFR Activated PLC gamma dissociates from the PDGF receptor SH2 domain of Src binds to the active receptor Downstream signal transduction Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Pubmed10508235 Pubmed1374684 Pubmed9739761 Reactome Database ID Release 43186763 Reactome, http://www.reactome.org ReactomeREACT_17025 Reviewed: Heldin, CH, 2008-11-23 19:29:34 The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.<br>Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules. PathwayStep3897 PathwayStep3857 PathwayStep3841