PathwayStep5252 PathwayStep5251 PathwayStep5254 PathwayStep5253 PathwayStep5256 PathwayStep5255 PathwayStep5257 PathwayStep5250 PathwayStep5249 PathwayStep5274 Extracellular processing of novel PDGFs PDGF binds to extracellular matrix proteins Processing of classical PDGFs Release of novel PDGFs as latent factors Translocation of PDGF from ER to Golgi Autophosphorylation of PDGF alpha/beta receptors PDGF dimer binds two receptors simultaneously Autophosphorylation of PDGF beta receptors Autophosphorylation of PDGF alpha receptors Downstream signal transduction Signaling by PDGF Authored: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Edited: Garapati, P V, Jassal, B, 2008-11-24 10:14:27 Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell. Pubmed10508235 Pubmed15207811 Pubmed9739761 Reactome Database ID Release 43186797 Reactome, http://www.reactome.org ReactomeREACT_16888 Reviewed: Heldin, CH, 2008-11-23 19:29:34