CREB phosphorylation ERK/MAPK targets PathwayStep3477 PathwayStep3472 Nuclear Events (kinase and transcription factor activation) An important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene expression. Transcription factors directly activated by neurotrophin signalling are responsible for induction of immediate-early genes, many of which are transcription factors. These in turn are involved in the induction of delayed-early genes. Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Pubmed8833451 Reactome Database ID Release 43198725 Reactome, http://www.reactome.org ReactomeREACT_12433 Reviewed: Greene, LA, 2007-11-08 15:39:37