Active Rac1 bound to Netrin-1-DCC complex Netrin:DCC oligomer:pFAK:Fyn:Nck-1:Rho GEFs DOCK/Trio RAC1-GDP Activation of Rac1 Authored: Garapati, P V, 2008-07-16 14:42:16 Edited: Garapati, P V, 2008-07-30 10:24:23 Pubmed18066058 Pubmed18212043 Reactome Database ID Release 43418856 Reactome, http://www.reactome.org ReactomeREACT_22200 Reviewed: Cooper, HM, 2010-02-16 Rho GEF's DOCK180 and Trio directly associate with DCC, activate Rac-1 on DCC stimulation and cause cell spreading.