UNC-5:Netrin-1 complex DCC bound to UNC-5:Netrin-1 DCC heterodimerizes with UNC-5:Netrin-1 Authored: Garapati, P V, 2008-07-16 14:42:16 Edited: Garapati, P V, 2008-07-30 10:24:23 Pubmed15960985 Reactome Database ID Release 43373713 Reactome, http://www.reactome.org ReactomeREACT_22173 Reviewed: Cooper, HM, 2010-02-16 UNC-5 uses DCC as a co-receptor and binds to the DCC P1 domain with its DB domain to repel axons at low netrin concentration. It is generally thought that UNC5 receptor alone transduces short range signals whereas DCC-Unc5 complex transduces long range signals important for neuron migration, neurite growth and axon repulsion.