PathwayStep5282 PathwayStep5281 NRP-1 forms a ternary complex with VEGF165 and VEGFR1 NRP-2 associates with VEGFR1 forming complexes on cell surface Neurophilin interactions with VEGF and VEGFR Authored: Krupa, S, Gopinathrao, G, 2007-03-08 22:07:59 Edited: Gopinathrao, G, 2007-04-08 21:14:18 Pubmed12613545 Reactome Database ID Release 43194306 Reactome, http://www.reactome.org ReactomeREACT_12473 Reviewed: Claesson-Welsh, L, 2008-02-28 00:15:17 The plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF-A165 and PLGF-2, as well as VEGF-A145 and -C. The Neurolipin receptors appear to act as cofactors for the VEGF receptors, increasing their affinities for specific VEGF ligands, although the importance of this function in vivo remains unclear (Neufeld et al. 2002). Detailed annotation of NRP interactions with VEGF proteins will be covered in future releases.