RAF/MAP kinase cascade PathwayStep5199 PathwayStep5198 PathwayStep5056 PathwayStep5055 PathwayStep5200 PathwayStep5201 PathwayStep5207 Phospho-Shc dissociates from the TrkA receptor SHC, complexed with TrkA, is tyrosine-phosphorylated SHC binds to the activated TrkA receptor GRB2:SOS binds to SHC-P SOS mediated nucleotide exchange of RAS (SHC) Feedback control in the MAPK signaling module Signalling to RAS Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 GENE ONTOLOGYGO:0007265 Pubmed11520933 Reactome Database ID Release 43167044 Reactome, http://www.reactome.org ReactomeREACT_12033 Reviewed: Greene, LA, 2007-11-08 15:39:37 Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells. p38MAPK events PathwayStep3857