RGD Neogenin:RGD Neogenin binds repulsive guidance molecules (RGDs) Among netrin1 receptors neogenin is the only protein to interact with the repulsive guidance molecules (RGM). RGMs are membrane bound proteins involved in axon guidance in the visual system. Neogenin is the dependence receptor and cleaved by activated caspase-3 to trigger apoptotic cell death. RGM binding blocks the cleavage of neogenin so RGM functions as a cell survival factor. Authored: Garapati, P V, 2008-07-16 14:42:16 Edited: Garapati, P V, 2008-07-30 10:24:23 Pubmed15258591 Pubmed15610137 Reactome Database ID Release 43374692 Reactome, http://www.reactome.org ReactomeREACT_22132 Reviewed: Cooper, HM, 2010-02-16