PathwayStep5208 PathwayStep5212 PathwayStep5226 Signalling to RAS Signalling to p38 via RIT and RIN Signalling to ERKs Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours. Pubmed10508738 Reactome Database ID Release 43187687 Reactome, http://www.reactome.org ReactomeREACT_12058 Reviewed: Greene, LA, 2007-11-08 15:39:37 Prolonged ERK activation events